Department of Medicine Faculty Profile

Alan Leff
Section of Pulmonary / Critical Care
Professor of Medicine
Committee of Molecular Medicine, Clinical Pharmacology and Pharmacogenomics and Cell Physiology
e-mail: aleff@medicine.bsd.uchicago.edu
Referring Physician Access Line: 1-877-DOM-2730

Training:

Degree	Year	Institution	Area
BA	1967	Oberlin College	Biology
MD	1971	University of Rochester
Residency	1976	University of Michigan	Internal Medicine
Fellowship	1977	University of California	Pulmonary Medicine

Academic Interests:

Dr. Leff is interested in the immunology of granulocytes in idiopathic inflammation, cell adhesion, inflammatory cell biology and regulation of inflammation by phospholipase directed signalling proteins.

Clinical Interests:

Asthma, COPD, respiratory physiology, occupational medicine

Representative Publications:

Myou, S, Zhu X, Myo S, Boetticher E, Meliton A, Liu J, Lambertino A, Munoz NM and Leff AR. Activation of group IV cystolic PLA2 in human eosinophils by phosphoinositide 3-kinase through mitogen activated protein kinase-independent pathway. J. Immunol. (in press), 2003.
Myou S, Zhu X, Myo S, Boetticher E, Meliton AY, Liu J, Munoz NM, Leff AR. Blockade of airway inflammation and hyperresponsiveness by HIV-TAT-dominant negative Ras. J. Immunol. (in press), 2003.
Myou S, Zhu X, Boetticher E, Myo S, Meliton A, Lambertino A, Munoz NM, Leff AR. Blockade of focal clustering and active conformation of ß2-integrin-mediated adhesion of eosinophils to ICAM-1 caused by transduction of HIV TAT-dominant negative Ras. J. Immunol. 169:2670-2676, 2002.
Zhu X, Sano H, Kim K-P, Sano A, Boetticher EE, Munoz NM, Cho W, Leff AR. Role of MAP-kinase-mediated phosphorylation on cytosolic phospholipase PLA2 in arachidonic acid metabolism in human eosinopohil. J. Immunol. 167:461-468, 2001.
Myou S., Sano H, Fujimura M,Zhu X,Kurashima K,Kita T, Nakao S,Nonomura A, Kim KP,Shioya T, Munoz NM,Cho W, Leff AR. Blockade of eosinophil migration and aiway hyperresponsiveness by cLPA2-inhibition. Nature Immunol.2:145-149,2001.