Department of Medicine Faculty Profile

Suzanne Conzen
Section of Hematology / Oncology
Associate Professor of Medicine

e-mail: sconzen@medicine.bsd.uchicago.edu
Referring Physician Access Line: 1-877-DOM-2730

Training:

Degree	Year	Institution	Area
BA	1982	Brown University	Political Science
MS	1985	University of London	Immunology
MD	1987	Yale University
Residency	1990	Cornell University	Internal Medicine
Fellowship	1993	Dartmouth-Hitchcock Medical Center	Hematology/Oncology
Fellowship	1996	Howard Hughes Medical Institute	Molecular Virology
Fellowship	1998	The University of Chicago	Molecular Oncology

Academic Interests:

Dr. Conzen's laboratory uses both molecular approaches and animal models to study mechanisms that contribute to the development and progression of human breast cancer. Current projects include 1) defining glucocorticoid receptor signaling pathways in breast epithelium, 2) determining the role of ubiquitin modification of cellular kinases in breast cancer survival signaling pathways and 3) using bioinformatic approaches to predict signaling pathways from large-scale time course microarray data.

Clinical Interests:

Locally advanced breast cancer

Representative Publications:

Wu W, Chaudhuri S, Brickley DR, Pang D, Karrison T, Conzen SD. Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells. Cancer Res. 2004; 64(5):1757-64.
Poelman SM, Heimann R, Fleming GF, Recant WM, Conzen SD. Invariant p53 immunostaining in primary and recurrent breast cancer. Eur J Cancer. 2004; 40(1):28-32.
Brickley DR, Mikosz CA, Hagan CR, Conzen SD.Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1).J Biol Chem. 2002; 277(45):43064-70.
Mikosz CA, Brickley DR, Sharkey MS, Moran TW, Conzen SD. Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1. J Biol Chem. 2001; 276(20):16649-54.
Moran TJ, Gray S, Mikosz CA, Conzen SD. The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer Res. 2000; 60(4):867-72.