Department of Medicine Faculty Profile

Louis Philipson
Section of Endocrinology, Diabetes and Metabolism
Professor of Medicine

e-mail: l-philipson@uchicago.edu
Referring Physician Access Line: 1-877-DOM-2730

Training:

Degree	Year	Institution	Area
BA	1976	Harvard University	Biochemistry
PhD	1982	The University of Chicago	Biochemistry
MD	1986	The University of Chicago
Residency	1990	The University of Chicago	Internal Medicine
Fellowship	1991	The University of Chicago	Endocrinology, Diabetes and Metabolism

Academic Interests:

Dr. Philipson’s research focuses on how pancreatic Beta-cells “know” when to secrete insulin and define defects in this process in diabetes that could be therapeutic targets. His focus is the study of ion channels, metabolism, and mitochondria that together regulate intracellular calcium concentration and energy production and thereby regulate insulin secretion in pancreatic islet Beta-cells. He is studying such processes as exocytosis of single insulin granules and production of reactive oxygen species in normal and diabetic mice and in human islets.

Clinical Interests:

Diabetes, hypoglycemia, transplantation, and general endocrinology.

Representative Publications:

Ma, L., V. P. Bindokas, A. Kuznetsov, C. Rhodes, L. Hays, J. M. Edwardson, K. Ueda, D. F. Steiner and L. H. Philipson. Direct Imaging Shows Insulin Granule Exocytosis Occurs by Complete Vesicle Fusion. Proc Natl Acad Sci USA 101:9266-71, 2004
Fridlyand, L.E., and Philipson, L.H. Does the Glucose-dependent Insulin Secretion Mechanism Itself Cause Oxidative Stress in Pancreatic â-cells? Diabetes (Perspective) 53:1942-1948, 2004
Fridyland, L.E., Tamarina, T., and Philipson, L.H. Modelling of Ca2+ flux in pancreatic ß-cells: role of plasma membrane and intracellular stores. Am J. Physiol 285:E138-54, 2003.
Bindokas, V.P., Kuznetsov, A., Sreenan, S., Polonsky, K.S., and Philipson, L.H. Visualizing Superoxide Production in Normal and Diabetic Rat Islets of Langerhans. J Biol Chem. 278: 9796-9801, 2003
Houamed, K., Fu, J., Roe, M.W., and Philipson L.H. “Electrophysiology of the Pancreatic â-cell”, Chapter in “Diabetes Mellitus: A Fundamental and clinical text, 3/e, Edited by LeRoith, D., Taylor, S.I., and Olefsky, J.O., Lippincott, Williams and Wilkins, pub. 2004