Department of Medicine Faculty Profile

Dan Nicolae
Section of Genetic Medicine
Associate Professor of Medicine

e-mail: dnicolae@medicine.bsd.uchicago.edu

Training:

Degree	Year	Institution	Area
BA	1995	University of Bucharest	Mathematics
PhD	1999	The University of Chicago	Statistics
Fellowship	2000	UCLA	Functional Genomics Program, IPAM

Academic Interests:

Dr. Nicolae research falls into three areas: the genetics of complex diseases, with an emphasis on inflammatory bowel disease and asthma related phenotypes, statistical genetics, and theoretical statistics.The current focus of his statistical genetics research is on methods for genome-wide association studies, including tools for quantifying and extracting the available information, multi-locus models and testing for gene-environment interaction.

Representative Publications:

Nicolae DL (2006) ``Quantifying the Amount of Missing Information in Genetic Association Studies''. Genetic Epidemiology, 30(8): 703-717.
Nicolae DL (2006) ``Testing untyped alleles (TUNA) - applications to genome-wide association studies''. Genetic Epidemiology, 30(8): 718-727.
Nicolae DL, Wen X, Voight BF, Cox NJ (2006) ``Coverage and characteristics of the Affymetrix GeneChip Human Mapping 100K SNP set''.PLoS Genetics, 2(5), e67.
Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee A, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH (2006) ``A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene.''. Science, 314 (5804), 1461 - 1463.
Nicolae D, Cox NJ, Lester LA, Schneider D, Tan Z, Billstrand C, Kuldanek S, Donfack J, Kogut P, Patel NM, Goodenbour J, Howard T, Wolf R, Koppelman GH, White SR, Parry R, Postma DS, Meyers D, Bleecker ER, Hunt JS, Solway J, Ober C (2005), ``Fine Mapping and Positional Candidate Studies Identify HLA-G as an Asthma Susceptibility Gene on Chromosome 6p21''. American Journal of Human Genetics, 76(2), 349-357.