Department of Medicine Faculty Profile

Elizabeth McNally
Section of Cardiology
Professor of Medicine
Director, Institute for Cardiovascular Research; Director, Cardiovascular Genetics Clinic
e-mail: emcnally@medicine.bsd.uchicago.edu
Referring Physician Access Line: 1-877-DOM-2730

Training:

Degree	Year	Institution	Area
BA	1983	Columbia University	Biology and Philosophy
MS	1990	Albert Einstein College	Microbiology and Immunology
MD	1990	Albert Einstein College
PhD	1990	Albert Einstein College	Microbiology and Immunology
Residency	1992	Brigham and Women's Hospital	Internal Medicine
Fellowship	1996	Brigham and Women's Hospital	Cardiovascular Medicine
Fellowship	1996	Howard Hughes Medical Institute	Genetics

Academic Interests:

Dr. McNally studies the genetics of heart and muscle disease. Her laboratory examines mechanisms by which genetic mutations lead to cardiomyopathy, arrhythmias and vascular spasm. Her laboratory studies the dystrophin glycoprotein complex, including the sarcoglycans, which help stabilize the plasma membrane of cardiac and skeletal muscle. The laboratory is also interested in proteins that play a role in membrane repair in skeletal and cardiac muscle and in proteins at the nuclear membrane and their role in cardiac and skeletal muscle function. Dr. McNally also directs the Cardiovascular Sciences Training Grant.

Clinical Interests:

Cardiomyopathy, inherited forms of heart disease, cardiac complications of muscle disease

Representative Publications:

McNally, E. M. Powerful genes: Myostatin in the regulation of human muscle mass. (2004) N. Engl. J. Med. 350(26):2642-4.
Chutkow, W.A., J.L. Pu, M.T. Wheeler,J.C. Makielski, C.F. Burant and E.M. McNally. Prinzmetal like vasospasm, hypertension and early death result from mutant Sur2 KATP channels in mice. (2002) J. Clin. Invest. 110:203-208
Doherty, K. R. and E. M. McNally. Repairing the tears: dysferlin in muscle membrane repair. (2003) Trends Mol. Med. 8:327-30.
Lapidos, K. A., R. Kakkar, E. M. McNally. The Dystrophin Glycoprotein Complex: Structure and Function in Cardiac and Skeletal Muscle. (2004) Circ. Res. 94:1023-31
Wheeler, M.T., M.J. Allikian, A. Heydeman, M. Hadhazy, S. Zarnegar and E. M. McNally. Smooth muscle cell extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan mutant cardiomyopathy. J Clin Invest. (2004) 113:668-75.