Department of Medicine Faculty Profile

Rachel Leproult
Section of Endocrinology, Diabetes and Metabolism
Research Associate (Assistant Professor)

e-mail: rleproul@uchicago.edu

Training:

Degree	Year	Institution	Area
BS	1991	Université Libre de Bruxelles	Mathematics
PhD	2001	Université Libre de Bruxelles	Biomedical Sciences

Academic Interests:

Dr. Leproult's research interest focuses on the health implications of sleep loss and circadian misalignment in humans. She has studied subjective sleepiness, cognitive function, electroencephalography, metabolic and endocrine function under different conditions of sleep duration and timing. Her specific area of expertise is the quantification of alterations in the daily profiles of neurobehavioral, endocrine and metabolic variables.

Representative Publications:

Leproult R., Van Reeth O., Byrne M.M., Sturis J., Van Cauter E. Sleepiness, performance, and neuroendocrine function during sleep deprivation: effects of exposure to bright light or exercise. J. Biol. Rhythms 12: 245-258, 1997.
Spiegel K, Leproult R, Van Cauter E. Impact of a sleep debt on metabolic and endocrine function. The Lancet, 354: 1435-1439, 1999.
Van Cauter E, Leproult R and Plat L. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA 284: 861-868, 2000.
Leproult R., Colecchia E.F., Berardi A.M., Stickgold R., Kosslyn S.M. Van Cauter E. Individual differences in subjective and objective alertness during sleep deprivation are stable and unrelated. Am. J. Physiol., Regul. Integr. Comp. Physiol., 284 (2): R280-290, 2003.
Spiegel K, Leproult R, L'Hermite-Balériaux M, Copinschi G, Penev P and Van Cauter E. Impact of sleep duration on the 24-hour leptin profile: relationships with sympatho-vagal balance, cortisol and TSH. J Clin Endocrinol Metab, 89(11):5762-5771, November 2004