Department of Medicine Faculty Profile

Shahid Siddiqui
Section of Pulmonary / Critical Care
Research Associate (Associate Professor)

e-mail: ssiddiqu@medicine.bsd.uchicago.edu

Training:

Degree	Year	Institution	Area
BSc	1969	J.M.I. University, New Delhi, India	Physics
MSc	1971	Aligarh M. University, Aligarh, India	Biochemistry
PhD	1978	Tata Institute of Fundamental Research, Bombay University	Molecular Biology
Fellowship	1978	Max Planck -Institute for Experimental Medicine	Molecular Biology

Academic Interests:

Dr. Siddiqui's focus is to discover and characterize candidate genes and genetic mechanisms that affect lung endothelial permeability and homeostasis. By performing genetic screens in the nematode C. elegans and combining this work with a functional analysis in microvessel endothelial monolayer, he has previously identified novel components that regulate monolayer integrity and molecular flux into and across the endothelium. He also studies kinesin motors mediating vesicular traffic in endocytosis and exocytosis in endothelium. Currently he has established novel approaches of inquiry such as the role of micro-RNAs in hypoxia and lung injury. He is developing transgenic animal models to study myosin light chain kinase (MLCK) gene in which genetic variants have been identified by the Garcia Lab that affect African Americans and cause severe asthma.

Representative Publications:

Siddiqui SS, Siddiqui ZK, Uddin S, Minshall R., and Malik AB. p38 MAPK Activation Coupled to Endocytosis is a Determinant of Endothelial Monolayer Integrity. Am J Physiol Lung Cell Mol Physiol.: 292: L114-L124. 2007
Frey R. Javed K, Rahman A., Siddiqui SS, Malik AB. Phosphatidylinositol 3-kinase {gamma} signaling via PKC {zeta} mediates NADPH oxidase-induced oxidant generation and NF- {kappa} B activation in endothelial cells. J Biol Chem. 281:16128-16138, 2006
Siddiqui SS, Siddiqui ZK, Malik AB. Albumin endocytosis in endothelial cells induces TGF-beta receptor II signaling. Am J Physiol Lung Cell Mol Physiol.; 286: 1016-26. 2004
Nakamura H, Siddiqui SS, Shen X, Malik AB, Pulido JS, Kumar NM, Yue BY. RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis. Mol Vis.; 10: 703-711. 2004
Yau DM, Yokoyama N, Goshima Y, Siddiqui ZK, Siddiqui SS, Kozasa T. Identification and molecular characterization of the G alpha12-Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegans. Proc Natl Acad Sci U S A.; 100(25):14748-53. 2003