Minoli Perera
Section of Genetic Medicine
Assistant Professor of Medicine

Training

DegreeYearInstitutionArea
BS1997Christian Brothers UniversityBiology
Pharm.D.2001University of TennesseePharmacy
PhD2003The Ohio State UniversityPharmaceutics
Fellowship2006 University of Chicago Clinical Pharmacology and Pharmacogenomics

Academic Interests

Dr. Perera is a Pharm. D./Ph.D. with expertise in pharmacokinetics, clinical pharmacology and human genetics. Her research focus involves extending our current understanding of the genetic variation affecting steady-state warfarin levels in African Americans, a major patient population at the University of Chicago that has been poorly studied to date for genes implicated in warfarin dosing. She plans to use these studies on warfarin to help build a foundation for further multidisciplinary research that will allow the development of an economically sustainable program in clinical pharmacogenetics, including a consult service. Her overall goal is to bring meaningful translation of pharmacogenetics research findings into clinical care.


Representative Publications

  1. Perera MA, Thirumaran RK, Cox NJ, Hanauer S, Das S, Brimer-Cline C, Lamba V, Schuetz EG, Ratain MJ, Di Rienzo A. Prediction of CYP3A4 enzyme activity using haplotype tag SNPs in African Americans. The Pharmacogenomics Journal, 2009 Feb;9(1):49-60 PMCID: PMC2754748
  2. Perera MA, Innocenti F, Das S, Ratain MJ. Are we there yet? UGT1A1 and Pharmacogenetic testing. Invited review, Pharmacotherapy 28(6): 755-768, 2008. PMID: 18503403 [PMCID -in process]
  3. Perera MA. The Missing Linkage: What pharmacogenetic associations are left to find in CYP3A? Invited Review. Expert Opinion on Drug Metabolism. Jan;6(1):17-28 (2010) PMID: 19968573 [PMCID - PMC2754748]
  4. Lodolce JP, Kolodziej LE, Rhee L, Kariuki SN, Franek BS, McGreal NM, Logsdon MF, Bartulis SJ, Perera MA, Ellis NA, Adams EJ, Hanauer SB, Jolly M, Niewold TB, Boone DL. African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity. J Immunol. 2010 Jun 15;184(12):7001-9.
  5. Perera MA, Gamazon E, Cavallari LH, Patel SR, Flynn M, Poindexter S, Kittles RA, Nicolae DA, Cox NJ. The Missing Association: Sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African Americans. Clinical Pharmacology and Therapeutics, Mar;89(3):408-15, 2011.



More Information

For more information about Dr. Minoli Perera publications and research collaborations , please click here