Section of Endocrinology, Diabetes and Metabolism
Associate Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730
|Residency||1995||Beth Israel Hospital||Internal Medicine
|Fellowship||1998||Beth Israel Deaconess Medical Center||Endocrinology
Dr. Cohen studies the role of nuclear receptor corepressors in hormone action. The thyroid hormone (TR) and retinoic acid (RAR) receptors bind nuclear receptor corepressors, including NCoR (nuclear receptor corepressor) and SMRT (silencing mediator of retinoid and thyroid hormone receptors) in the absence of their respective ligands. Dr. Cohen has shown that the TR preferentially binds NCoR, whereas RAR prefers to recruit SMRT. His current work investigates the roles of these proteins in important endocrine tissues, such as the adipocyte. In addition, a mutation in the pituitary-specific repressor Hesx1 has been identified in a patient with congenital hypopituitarism and septo-optic dysplasia, and Dr. Cohen continues ongoing work to elucidate the molecular mechanisms of pituitary dysfunction caused by this mutation.
Hyperthyroidism and hypothyroidism, thyroid cancer, pituitary disorders, general endocrinology
- Cohen RN, Cohen LE, Botero D, Yu C, Sagar A, Jurkiewicz M, Radovick S. Enhanced repression by HESX1 as a cause of hypopituitarism and septo-optic dysplasia. 2003. J Clin Endocrinol Metab; 88: 4832-4839
- Shibusawa N, Hashimoto K, Nikradhanond AA, Liberman MC, Applebury ML, Liao XH, Robbins, JT, Refetoff S, Cohen RN, Wondisford FE. Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo. 2003. J Clin Invest; 112: 588-597.
- Makowski A, Brozostek S, Cohen RN, Hollenberg AN, Determination of nuclear receptor corepressor interactions with the thyroid hormone receptor, Mol. Endocrinol. 2003;17:273-286.
- Pohlenz J, Dumitrescu A, Zundel D, Martine U, Schonberger W, Koo E, Weiss RE, Cohen RN, Kimura S, Refetoff S. Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in human and mice. J Clin Invest. 2002; 109; 469-473.
- Cohen RN, Brzostek S, Kim B, Chorev M, Wondisford FE, Hollenberg AN. The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains. Mol. Endocrinol. 2001;15:1049-1061.