Michelle Le Beau
Section of Hematology / Oncology
Professor of Medicine
Arthur and Marian Edelstein Professor; Director, The University of Chicago Comprehensive Cancer Center; Director, Cancer Cytogenetics Laboratory
Training
| Degree | Year | Institution | Area |
| BS | 1976 | Purdue University | Genetics |
| MS | 1978 | University of Illinois | Pathology |
| PhD | 1981 | University of Illinois | Pathology |
| Fellowship | 1983 | The University of Chicago | Hematology/Oncology |
Dr. Le Beau’s research focuses on the molecular analysis of the recurring chromosomal abnormalities in human leukemias and lymphomas, correlating specific abnormalities with morphological and clinical features and the development of risk-adapted therapy. Ongoing projects include the molecular cloning of a myeloid leukemia-related gene involved in the –5/del(5q) characteristic of therapy-related acute myeloid leukemia; genetic characterization of murine models recapitulating the genetic mutations in acute myeloid leukemia and identification of secondary, cooperating mutations and genetic pathways to leukemogenesis; and the application of murine models for pre-clinical drug testing and elucidation of the mechanism for the genetic instability characteristic of chromosomal fragile sites.
- Lai, F., Godley, L.A., Joslin, J., Fernald, A.A., Liu, J., Espinosa, R. 3rd, Zhao, N., Pamintuan, L., Till, B.G., Le Beau, M.M. Transcript map and comparative analysis of the 1.5 Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). Genomics 71:235-245, 2001.
- Corbin, S., Neilly, M.E., Espinosa, R. 3rd, Davis, E.M., McKeithan, T.W., Le Beau, M.M. Identification of unstable sequences within the common fragile site at 3p14.2: Implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors. Cancer Res 62:3477-3484, 2002
- Qian, Z., Fernald, A.A., Godley, L.A., Larson, R.A., Le Beau, M.M. Expression profiling of CD34+ hematopoietic stem/progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia. Proc Natl Acad Sci USA 99:14925-14930, 2002.
- Le Beau, M.M., Davis, E.M., Patel, B., Phan, V.T., Sohal, J., Kogan, S.C. Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice identify cooperating events and genetic pathways to acute promyelocytic leukemia. Blood 102:1072-1074, 2003.
- Smith, S.M., Le Beau, M.M., Huo, D., Karrison, T., Sobecks, R.M., Anastasi, J., Vardiman, J.W., Rowley, J.D., Larson, R.A. Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood, 102:43-52, 2003.